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Biodegradable Materials

Patents with Abstracts

*8/1/2013  

from 4/23/2012

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Patent Abstracts

10. Biodegradable Macromonomers

U.S. Patent 8,492,505 (July 23, 2013),”Branched Biodegradable Polymers, a Macromonomer, Processes for the Preparation of Same, and their Use,”
Jan Feijen, Zhiyuan Zhong, and Pieter Jelle Dijkstra (University of Twente, Enschede, Netherlands).

Branched biodegradable polymers are needed for medical and non-medical applications.  A bidogradable macromonomer is needed for preparing different biodegradable materials for specific applications.  Feijen, Zhong and Dijkstra developed branched biodegradable polymers by preparing a macromonomer by ring-opening polymerization of at least one cyclic ester, cyclic carbonate or cyclic carboxyanhydride with a branching agent and a catalyst followed by polycondensation of the macromonomer with other monomers by ring-opening polymerization to form the final material.

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9. 8,492,505 
Branched biodegradable polymers, a macromonomer, processes for the preparation of same, and their use 

Feijen, Zhong and Dijkstra of the University of Twente, Enschede, Netherlands, developed branched biodegradable polymers by (a) preparing a macromonomer by ring-opening polymerization of at least one cyclic ester, cyclic carbonate, and/or cyclic carboxyanhydride in the presence of a branching agent and optionally a catalyst; and (b) subsequent polycondensation of the macromonomer, to a process for the preparation of a macromonomer by ring-opening polymerization of at least one cyclic ester, carbonate and/or N-carboxyanhydride in the presence of a defined branching agent and optionally a catalyst. 

8. 8,258,254 
Biodegradable resin, biodegradable resin composition, biodegradable molded object, and process for producing biodegradable resin
 
Inoue, Yamashiro and Iji of the NEC Corporation developed biodegradable resin with good  heat resistance, molding and recycling properties by a covalently bonded and thermo-reversible cross-linked structure using hydroxyl grous. Heat resistance, molding property, recycling property and biodegradability can be further improved, if necessary, by setting the cleaving temperature of a cross-linked structure in a given range, selecting the kind of a cross-linked structure, and making a three-dimensional cross-linked structure. (RDC 9/22/2012)

7. 8,242,073 
Biodegradable and bioabsorbable biomaterials and keratin fibrous articles for medical applications
 
Li et al of The Hong Kong Polytechnic University, China, produced biodegradable and/or bioabsorbable biomaterials and keratin nonwoven fibrous articles by electrospinning fibers from a blend of biomaterials and keratin dissolved in organic solvents includes generating a high voltage electric field between oppositely charged biomaterials and keratin fluid in a syringe with a capillary tip and a metallic collection roller and causing a jet to flow to the roller as solvent evaporates and collecting fibrous membranes or scaffolds on the roller. Keratin increased the cell affinity of biomaterial scaffolds which have potential medical applications. (RDC 8/29/2012)

6. 8,232,348 
Masterbatch and polymer composition
 
Changping of Biograde (Hong Kong) Pty Ltd., China, developed a biodegradable material by melt mixing a first biodegradable polyester and a masterbatch, wherein said masterbatch has been formed separately by melt mixing in the presence of a transesterification catalyst a polysaccharide, a second biodegradable polyester and a biodegradable polymer having pendant carboxylic acid groups. (RDC 8/11/2012)

5. 8,187,514 
Biodegradable molded article
 
Ozasa, Hashimoto and Tanaka of the Nissei Company, Japan, developed a coated bowl-shaped container which is biodegradable.  It consists mainly of starch. The main body is molded through steam expansion of a slurry or dough molding material containing high-amylose starch and water, or a slurry or dough molding material containing starch, polyvinyl alcohol and water.  (RDC 6/6/2012)

4. 8,187,254 
Biodegradable drains for medical applications
 
Hissink et al of Polyganics developed drains for draining fluids (liquids and/or gases) from antrums or other parts of the human or animal body from synthetic biodegradable material, preferably a biodegradable polymer. The majority of biocompatible, biodegradable synthetic materials that are being used in medical devices is based on synthetic polyesters made of (mixtures of) cyclic lactones such as glycolide, lactide, .epsilon.-caprolactone, para-dioxanone, trimethylenecarbonate and of polyesters made by a condensation reaction of diols and diacids or hydroxyalkanoic acids. These polyesters can be used as such or in combinations with polyethers, polyurethanes, polyamides or with organic or inorganic compounds (RDC 6/5/2012)

3. 8,137,603 
Bioabsorbable polymeric composition for a medical device
 
Thatcher and Cottone, Florida, developed a biodegradable and biocompatible nontoxic polymeric composition including a base such as a crystallizable polymer, copolymer, or terpolymer and a copolymer or terpolymer additive.  Usually  a poly (L-lactide), and/or a poly (D-lactide) is the base polymer.  The copolymers are  block copolymers or  "blocky" random copolymers.  The lactide chain length of copolymers may be selected to be sufficiently long enough to crystallize. Shortened degradation time, to provide, for example, enhanced degradation kinetics may be obtained by using a lower molecular weight composition and/or a base polymer that is more hydrophilic or suspect to hydrolytic chain scission. For example, the copolymer may be poly L(or D)-lactide-co-tri-methylene-carbonate, or poly L(or D)-lactide-co-.epsilon.-caprolactone, which may link the base polymers.  In such copolymer-modifying copolymer embodiment, the composition may allow the development of a crystal morphology that can enhance the mechanical properties of the medical device, enhance processing conditions, and provide potential of cross crystallization, for example, strain induced thermal cross-links.  The modifying polymer or co-polymer may also be used to affect enhanced degradation kinetics, such as with an .epsilon.-caprolactone copolymer moiety where the caprolactone remains amorphous with resulting segments more susceptible to hydrolysis. (RDC 5/14/2012)

2. 8,133,968 
Poly(orthoester) polymers, and methods of making and using same
 
Alkatout, Benz and Sparer of Medtronic, Minnesota, synthesized poly(orthoester) polymers. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.  (RDC 5/4/2011)

1. 8,129,477 
Medical devices and methods including blends of biodegradable polymers
 
Zhang, Lyu and Schley of Medtronic, Inc., Minnesota, developed an implantable, biodegradable  medical device using a polymer blend. This blend includes: a first phase that is continuous and a discontinuous second phase The first continuous phase has a glass transition temperature of at least 40.degree. C. such as, a polylactide homopolymer or copolymer.  The chains of the first biodegradable polymer are oriented.  The second phase has a glass transition temperature of 15.degree. C. or less and includes a second biodegradable polymer such as poly(trimethylene carbonate) (PTMC), polycaprolactone (PCL), polyhydroxybutyrate, and combinations thereof). (RDC 4/23/2012)

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Roger D. Corneliussen
Editor
www.maropolymeronline.com

Maro Polymer Links
Tel: 610 363 9920
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E-Mail: cornelrd@bee.net  

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Copyright 2012 by Roger D. Corneliussen.
No part of this transmission is to be duplicated in any manner or forwarded by electronic mail without the express written permission of Roger D. Corneliussen
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** Date of latest addition; date of first entry is 4/23/2012.