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Controlled Release

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Patent Abstracts

10 8,362,113 
Self-repairing concrete having polyurethane polymer micro-capsules and method for fabricating the same 

Xing and Zhuo, China, developed a self-repairing concrete using a predetermined amount of concrete, micro-capsules and water with mass ratio of the concrete, micro capsules, and water is 100:1-15:15-50.  (RDC 2/6/2013)

9. 8,242,056 
Agriculture actives delivery composition comprising boron and persulfate ion-crosslinked polyvinyl alcohol microcapsules and method of use thereof
Bobnock of Appleton Papers Inc., Wisconsin, developed an aqueous suspension with a pH of 2.0 to 12.8 and boron or persulfate ion-crosslinked polyvinyl alcohol microcapsules for agriculture. (RDC 8/29/2012)8. 8,241,651 
Multiphasic biofunctional nano-components and methods for use thereof
Lahann of the University of Michigan, Michigan, developed multiphasic nanoparticles having at least two phases and at least one active ingredient are provided. These nanoparticles can be used in various methods for medical diagnostics or with pharmaceutical, personal care, oral care, and/or nutritional compositions, for example, in oral care, hair, or skin products. The nanoparticles can be designed to have targeted delivery within an organism, while providing controlled release systems or combining incompatible active ingredients. Further, they can be used as biomedical coatings (such as anti-microbial coatings), or anti-corrosive coatings, bioimaging probes with combined diagnostic and therapeutic use, and fragrance release systems, among others. The nanoparticles can be formed by electrified jetting of polymers. (RDC 8/17/2012)

7. 8,192,838 
Controlled release materials
Goodson and  Rodrigues of Akzo Nobel N.V., Netherlands, developed polymers whose water solubility may be triggered by changes in pH, salt concentration or surfactant concentration.  The polymer is a copolymer or terpolymer containing from 2 to 60 mole percent of an amine functionality that has been neutralized with a fixed acid.  Specifically films formed from these polymers will be insoluble at a higher pH, but will become soluble at a lower pH.  The polymers are also insoluble at a higher salt concentration, but become soluble at a lower salt concentration. The polymers can be used to coat or encapsulate active ingredients, that are released based on changes in the environment, such as in the rinse cycle of a dishwasher or laundry washing machine  (RDC 6/25/2012)

6. 8,187,617 
Immediate release compositions and methods for delivering drug formulations using weak acid ion exchange resins in abnormally high pH environments
Howard and Somma, New Jersey, found that adding a release enhancing agent with a strong affinity for the ionic resin to a weak acid resin drug formulation led to a much more rapid and complete release of a resinated drug can be attained in abnormal gastric fluid than otherwise would occur without the presence of the release enhancing agent in abnormal human gastric fluid wherein the pH is much higher than normal due to the use of drugs such as PPI or the presence of disease states such as H. pylori or atrophic gastritis that can lead to hypochlorhydria and achlorhydria. (RDC 6/6/2012)

5. 8,187,616 
Method for silk fibroin gelation using sonication
Wand et al of Tufts College, Massachusetts, developed a process of rapidly forming silk fibroin gelation through ultrasonication.  Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment.  Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles. (RDC 6/6/2012)

4. ,187,513 
Method for producing articles consisting of polymer materials having a medicamentous depot effect
Ludwig, Hemmer and Mertens of Veritas, Germany, developed plastics for the controlled release of drugs by mixing the starting materials, shaping the mixture, cross-linking, packaging and sterilizing with further cross-linking.  (RDC 6/6/2012)

3. 8,187,221 
Nanotube-reinforced balloons for delivering therapeutic agents within or beyond the wall of blood vessels, and methods of making and using same

Bates of Nexeon MedSystems, West Virginia, developed a dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen. (RDC 6/4/2012)

2. 8,137,581 
Chlorine dioxide releasing composite article
Speronello, Hratko and Cochran of BASF, New Jersey, developed a composite  that includes a ClO2-producing material integrated into an organic matrix and methods of using the same are described. The organic matrix of the composite article is formable at a temperature under about 150 C., permits contact between an activating stimulus (e.g., water vapor and/or electromagnetic energy) and the ClO2-producing material when the composite article is exposed to the activating stimulus, and is permeable to ClO2.  (RDC 5/14/2012)

1. 8,118,582 
Method and apparatus for producing biobased carriers from byproducts of biomass processing 

Ileleji and Probst;of Purdue, Indiana, produced biobased carriers for dispersal of biological and chemical molecules using a premixer for producing homogeneious mixtures, a high shear mixer to produce very small DDGS particles and an agglomerator to produce spherical pellets.  (RDC 3/29/2012)


Roger D. Corneliussen

Maro Polymer Links
Tel: 610 363 9920
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Copyright 2012 by Roger D. Corneliussen.
No part of this transmission is to be duplicated in any manner or forwarded by electronic mail without the express written permission of Roger D. Corneliussen

** Date of latest addition; date of first entry is 5s/14/2012.