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Controlled Release of Drugs

Patent Abstracts

From 06/23/2014 through 5/29/2012

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Patent Abstracts

6. 8,277,841 
Polyamide rate-modulated monolithic drug delivery system
 
Kolawole, Pillay and Choonara of the University of The Witwatersand, South Africa, developed  a polyamide rate-modulated monolithic drug delivery system consisting of an active compound and a biodegradable and biocompatible polyamide.  The polymer is selected for delivering, in use, the active compound, within a predetermined time frame depending on the biodegradable properties of the polymer, to a target organism or organisms. The polymer can be modified by salting-out or crosslinking the polymeric material to achieve the desired biodegradability characteristics and, consequently, to control the release of the active compound. (RDC 10/8/2012)

5. 8,277,840 
Sustained release formulation of alprazolam
 
Joshi, Gat and Mehta of Emcure Pharmaceuticals Limited, India, has developed a sustained release pharmaceutical composition comprising: (a) a therapeutically effective amount of alprazolam, (b) a high viscosity hydroxy-propyl-methyl cellulose (HPMC) and low viscosity hydroxy-propyl-methyl cellulose (HPMC) in a ratio of 65:35 to 85:15, and (c) pharmaceutically acceptable excipients. (RDC 10/8/2012)

4. 8,216,495 
Preparation method for solid dispersions
 
Janssens and Van Den Mooter of Formac Pharmaceuticals N.V., Belgium, prepared a solid dispersion of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR with a BCS Class II drug or a BCS Class IV drug.  The method consists of: a) dissolving the polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer) separately in a water/first alcohol mixture; and b) dissolving the BCS Class II drug or a BCS Class IV drug, in a mixture of a second alcohol with a non alcoholic organic solvent in which the compound has an high solubility; and c) mixing the both solutions to obtain a third solution with a total amount of solved solid of 1 to 15 g per 100 ml, and optionally having an acid, including inorganic acids including hydrohalic acids, e.g. hydrochloric or hydrobromic acid; sulfuric; nitric; phosphoric and the like acids; or organic acids including acetic, propanoic, hydroxyacetic, lactic, pyruvic, oxalic, malonic, succinic, maleic, fumaric, malic, tartaric, citric, methane-sulfonic, ethanesulfonic, benzenesulfonic, p-toluenesulfonic, cyclamic, salicylic, p-aminosalicylic, palmoic and the like acids in the mixture of both the solutions to achieve an acid pH; and d) spray drying the third solution. (RDC 7/25/2012)

3. 8,192,743 
Releasable polymeric conjugates based on aliphatic biodegradable linkers
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Zhao, Greenwald and Adler of Enzon Pharmaceuticals, New Jersey, developed activated polymeric bicine derivatives for controlled drug release. Bicine is 2-(Bis(2-hydroxyethyl)amino)acetic acid, N,N-Bis(2-hydroxyethyl)glycine, diethylolglycine or diethanol glycine or dihydroxyethylglycine (RDC 6/19/2012)

2. 8,178,656 
Silk-based drug delivery system
 
Kaplan and Lorenz of Tufts College, Massachusetts and Eidgenossisches Technische Hochschule, Switzerland, developed sustained release silk-based delivery systems.  A silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article.  The article is then treated in such a way as to alter its conformation.  The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer. (RDC 5/29/2012)

1. 8,178,499 
Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring
 
Bellini and Zanellato of Fidia Farmaceutici, Italy, developed hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives for forming hydrogels by photocuring.  These hydrogel are used in biomedical, sanitary and surgical fields and for controlled release of drugs.  (RDC 5/29/2012)

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Roger D. Corneliussen
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Copyright 2012 by Roger D. Corneliussen.
No part of this transmission is to be duplicated in any manner or forwarded by electronic mail without the express written permission of Roger D. Corneliussen
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** Date of latest addition; date of first entry is 5/29/2012.