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from 5/1/2012

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Patent Abstracts

6. 8,465,779 
 Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use 

A hydrogel material that permits cellular ingrowth and has controlled rate of expansion optimized for delivery through a microcatheter or catheter without the need for a non-aqueous solvent or a coating has not been developed. Accordingly, there remains a need in the art for the development of such a hydrogel useable as tissue compatible implants.

Cruise and Constant of MicroVention, Inc, California, developed a hydrogel sufficiently porous to permit cellular ingrowth for implants. The hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator.  If desired, a porosigen, (e.g., sodium chloride, ice crystals, and sucrose) is included.  Porosity is formed by the subsequent removal of the porosigen from the resultant solid hydrogel (e.g, by repeated washing).  The controlled rate of expansion is developed by adding ethylenically unsaturated monomers with ionizable functional groups such as amines or carboxylic acids,  In addition a stimulus-expandable hydrogel material of the present invention may be rendered radiopaque  radiopaque particles (e.g., tantalum, gold, platinum, etc.) into the liquid reaction mixture.  These hydrogels can be used for the treatment of aneurysms, fistulae, arterio-venous malformations and vessel occlusions. 

5. 8,241,567 
Hydrogel compositions
Cai, Berndt and Hartsell of Becton, Dickinson and Company, New Jersey, developed a hydrogel matrix, where the matrix comprises poly(ethylene glycol) dimethyacrylate (PEGDMA), an acrylate, such as methacrylic acid (MAA) and methyl methacrylate (MMA), as well as 2-hydroxy-2 methyl propiophenone (HMPP).  This hydrogel is used for binding proteins in biosensors. (RDC 8/17/2012)

4. 8,211,959 
Biodegradable copolymer hydrogels
Shen of the Industrial Technology Research Institute, Taiwan,  developed a biodegradable copolymer hydrogel consisting a two-phase block copolymer represented by A-B--BOX--B-A or B-A-B--BOX--B-A-B, wherein A is a hydrophilic block such as a hydrophilic polyethylene glycol polymer, B a hydrophobic block such as a hydrophobic polyester polymer, and BOX a bifunctional group monomer of 2,2'-Bis(2-oxazoline). The biodegradable copolymer hydrogel is prepared by cross-linking the di-block A-B or the tri-block B-A-B via ring-opening polymerization in presence of a bifunctional group monomer (2,2'-Bis(2-oxazoline)). (RDC 7/10/2012)

3. 8,178,663 
Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring

2. 8,178,499 
Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring
Bellini and Zanellato of Fidia Farmaceutici, Italy, developed hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives for forming hydrogels by photocuring.  These hydrogel are used in biomedical, sanitary and surgical fields and for controlled release of drugs.  (RDC 5/29/2012)

1. 8,133,509 
Hydrogels based on aliphatic NCO prepolymers
Kohler et al of Bayer, Germany, developed polyurethane hydrogels are obtained by the reaction of aliphatic isocyanate prepolymers with polyols comprising tertiary nitrogen in water. The process consists of  reacting: a) one or more nonionically hydrophilicized, aliphatic and/or cycloaliphatic polyisocyanate prepolymer which contains less than 1% by weight of monomeric diisocyanates, with b) one or more compounds having at least one tertiary amino group and at least three hydroxyl groups, c) water, and, optionally, d) one or more antimicrobially active metal salts and/or metal particles. (RDC 5/1/2012)


Roger D. Corneliussen

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Copyright 2012 by Roger D. Corneliussen.
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** Date of latest addition; date of first entry is 5/1/2012.