Maro Publications

Nanoparticles for Controlled Release



Maro Topics


Patent Abstracts

Patent Titles


Controlled Release



1. “Controlled released nano- or micro-particles can either enhance immunity by providing a long-term suppository or "depot" for antigen or can deliver complex molecules for mucosal or parental delivery. Often the size of these particles contributes to their effectiveness. Nano- and micro-particle uptake from the gastrointestinal track often involves the villus tips, enterocytes, and Peyer's patches. The factors controlling the extent of this uptake include, but are not limited to, size, hydrophobicity, surface charge, dose, and timing of food intake. Particles ranging 5 to 150 .mu.m enter via the villus tips, while enterocytes and other host cells take up particles <100 .eta.m in size. Peyer's patches are the predominant site of uptake for particles <10 .mu.m, with particles <5 .mu.m being transported into the lymph. Relatively positively surface-charged (>-0.1 mV) particles are more efficiently taken up by M cells that predominate the Peyer's patch. Hence, positively charged particles <1 .mu.m and >-0.1 mV may be favored for oral delivery of vaccines since they would presumably have a higher propensity to penetrate the mucosa. Similarly, nanoparticles (<200 nm) may be preferentially taken up by host cells (i.e., leukocytes, epithelial cells, cancer cells, etc.).” [Lillard, Singh and Singh, US Patent 8,231,907 (7/31/2012)]


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(RDC 6/5/2012)


Roger D. Corneliussen

Maro Polymer Links
Tel: 610 363 9920
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Copyright 2012 by Roger D. Corneliussen.
No part of this transmission is to be duplicated in any manner or forwarded by electronic mail without the express written permission of Roger D. Corneliussen

* Date of latest addition; date of first entry is 7/31/2012.