Maro Publications

Nanoparticles for Controlled Release

Patent Abstracts

from 8/9/2012

Maro Topics


Patents with Abstracts

3. 8,372,944 
Synthesis of hyperbranched amphiphilic polyester and theranostic nanoparticles thereof 

Perez and Santra produced hyperbranched amphiphilic polyesters by drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst.  The vacuum is then released with a dry inert gas after drying.  The dried mixture is heated under the inert gas at a temperature sufficient for polymerization.  The inert gas is evacuated while continuing to heat the mixture.  The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol.  Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.  (RDC 2/19/2013)

2. 8,242,165 
Mucoadhesive nanoparticles for cancer treatment
Dash and Trickler of Creighton University, Nebraska, developed nanoparticles including a glyceryl monooleate or monolinoleate (or other mono fatty acid ester); a chitosan; and a cancer therapeutic agent, such as gemcitabine, taxanes, and hydrophobic cancer therapeutic agents). These particles can be used for treating breast, pancreatic, colon, prostate, and other cancers by parenterally, intravenously, or other techiques. (RDC 8/29/2012)

1. 8,231,907 
Nanoparticles for delivery of active agents
Lillard, Singh and Singh of the Morehouse School of Medicine, Georgia, developed milled nanoparticles for delivering drugs.  5 nm to 60 micron nanoparticles are formed by planetary ball milling with active agents and coating materials with >99% loading efficiency. The active agents include fluorescent, bioluminescent, and/or radio-isotope agents in a biopolymer such as alginate, cellulose, starch or collagen.  The particle coatings contain polycaprolactone or polyethylene glycol or both. (RDC 8/9/2012)


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(RDC 6/5/2012)


Roger D. Corneliussen

Maro Polymer Links
Tel: 610 363 9920
Fax: 610 363 9921


Copyright 2012 by Roger D. Corneliussen.
No part of this transmission is to be duplicated in any manner or forwarded by electronic mail without the express written permission of Roger D. Corneliussen

** Date of latest addition; date of first entry is 8/9/2012.