Patents with Abstracts
Patents with Abstracts
Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals
Detamore et al of The University of Kansas, Kansas, developed a tissue engineering scaffold for growing cells linking biocompatible microspheres together to form a three-dimensional matrix. The matrix includes pores for growing cells. The biocompatible microspheres can include first and second sets of microspheres. The first set of microspheres can have a first characteristic, and a first predetermined spatial distribution with respect to the three-dimensional matrix. The second set of microspheres can have a second characteristic that is different from the first characteristic, and a second predetermined spatial distribution that is different from the first predetermined spatial distribution with respect to the three-dimensional matrix. The first and second characteristics can selected a composition, polymer, particle size, particle size distribution, type of bioactive agent, type of bioactive agent combination, bioactive agent concentration, amount of bioactive agent, rate of bioactive agent release, mechanical strength, flexibility, rigidity, color, radiotranslucency and radiopaqueness. (RDC 10/8/2012)
Nano/macroporous bone tissue scaffolds for regenerative medicine
Jain et al of Lehigh University, Pennsylvania, developed a biocompatible inorganic porous material having a three-dimensional coexistent network of interconnected macro-pores and nanopores produced by the steps of mixing an organic water-soluble polymer (e.g., polyethylene oxide or a block copolymer of ethylene oxide and propylene oxide), an alkoxysilane, and an inorganic water-soluble calcium salt in an aqueous acid solution, such that a sol-gel process of hydrolysis and polycondensation is initiated and thereby producing a gel; drying the gel to remove solvent by evaporation; and heating the gel to remove the polymer by thermal decomposition, thereby forming an inorganic porous material, which may be suitable for use as a bone tissue scaffold. (RDC 10/8/2012)
Yamazaki and Ishihara of FUJIFILM, Japan, developed a porous film as a cell culture substrate that is a scaffold for a spheroid. The porous film has a plurality of pores whose diameters gradually increase in a direction A. The diameters of the pores gradually increase from a first area P1 to a third area P3 in this order. The first to the third areas P1 to P3 are located on the porous film along the direction A. The diameters and depths of the pores increase in proportion to the distance in the direction A. (RDC 6/7/2012)
Hydroxyphenyl cross-linked macromolecular network and applications thereof
Calabro, Darr and Gross of the Cleveland Clinic Foundation, Ohio, developed a dihydroxyphenyl cross-linked macromolecular network for tissue engineering for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties. (RDC 5/16/2012)
Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof
Laurencin et al of Drexel University, the Wistar Institute and the University of Pennysylvania, Pennsylvania, developed scaffolds for tissue engineering from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Microcarriers with densities as light as water or 1.0 g/cc can also be used. Using PLAGA to produce microcarriers of the present, the majority of lighter than or light as water microcarriers (47%) were within the range of 500 to 860 .mu.m in diameter, with 19% from 300-500 .mu.m, 8% at 100-300 .mu.m and 2% less than 100 .mu.m. (RDC 5/15/2012)
Nonwoven tissue scaffold
Kladakis et al of DePuy Mitek, Massachusetts, developed a biocompatible meniscal repair device. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold consists of a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength. The meniscus is specialized tissue found between the bones of a joint. For example, in the knee the meniscus is a C-shaped piece of fibrocartilage which is located at the peripheral aspect of the joint between the tibia and femur. This tissue performs important functions in joint health including adding joint stability, providing shock absorption, and delivering lubrication and nutrition to the joint. As a result, meniscal injuries can lead to debilitating conditions such as degenerative arthritis. Preferably, the nonwoven material of the scaffold of the present invention is formed from one or more biocompatible polymers including at least one polymer derived from monomer(s) selected from the group consisting of glycolide, lactide, caprolactone, trimethylene carbonate, polyvinyl alcohol, and dioxanone. In one embodiment, the scaffold is comprised of bioabsorbable polymers. (RDC 5/15/2012)
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Roger D. Corneliussen
Maro Polymer Links
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Copyright 2012 by Roger D. Corneliussen.
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** Date of latest addition; date of first entry is 10/8/2012.