Tissue Engineering
Scaffolds
8/22/2008
“Cells are often implanted or 'seeded' into an artificial structure capable of supporting three-dimensional tissue formation. These structures, typically called scaffolds, are often critical, both ex vivo as well as in vivo, to recapitulating the in vivo milieu and allowing cells to influence their own microenvironments. Scaffolds usually serve at least one of the following purposes:
Allow cell attachment and
migration
Deliver and retain cells and biochemical factors
Enable diffusion of vital cell nutrients and expressed products
Exert certain mechanical and biological influences to modify the behaviour of
the cell phase”
Wikipedia:
http://en.wikipedia.org/wiki/Tissue_engineering (11/22/2008)
Dextran Scaffolds
Fibrin Scaffolds
Imaging Tissue Growth
Microfluidic Scaffolds
Poly(lactic-co-glycolic)acid (PLGA) Scaffolds
Polymethylmethacrylate (PMMA) Scaffolds
Warning: Sometimes the older links no longer work. Go to the US Patent number search page, copy the Patent number into the search box and search. For the articles, use your browser to go the Journal site.
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Notes
“To achieve the goal of tissue reconstruction, scaffolds
must meet some specific requirements. A high porosity and an adequate pore size
are necessary to facilitate cell seeding and diffusion throughout the whole
structure of both cells and nutrients. Biodegradability is often an essential
factor since scaffolds should preferably be absorbed by the surrounding tissues
without the necessity of a surgical removal. The rate at which degradation
occurs has to coincide as much as possible with the rate of tissue formation:
this means that while cells are fabricating their own natural matrix structure
around themselves, the scaffold is able to provide structural integrity within
the body and eventually it will break down leaving the neotissue, newly formed
tissue which will take over the mechanical load. Injectability is also important
for clinical uses.”
Wikipedia:
http://en.wikipedia.org/wiki/Tissue_engineering (11/22/2008)
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Review Articles
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US Patents
11/18/2008
7,452,720
Apparatus for preparing a biocompatible matrix
7,452,491
Method for forming scaffolds
11/11/2008
7,449,180
Macroscopic scaffold containing amphiphilic peptides encapsulating cells
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Journal Articles
2/6/2009
Synthesis of Unprecedented Scaffold Diversity
(p 1194-1196)
Angewandte Chemie International Edition 48 #7 (2009)
Abstract
1/23/2009
Cell Distribution in a Scaffold with Random
Architectures under the Influence of Fluid Dynamics
(229-245)
Journal of Biomaterials Applications 23, #3 (2009)
[Abstract]
Tuning of cell proliferation on tough gels by
critical charge effect
(p 74-83)
Journal of Biomedical Materials Research 88A #1 (2009)
Abstract
Boronate-containing polymer brushes:
Characterization, interaction with saccharides and mammalian cancer cells
(p 213-225)
Journal of Biomedical Materials Research 88A #1 (2009)
Abstract
Effect of 3D-microstructure of bioabsorbable
PGA:TMC scaffolds on the growth of chondrogenic cells
(p 92-102)
Journal of Biomedical Materials Research 88B #1 (2009)
Abstract
Multinozzle low-temperature deposition system for
construction of gradient tissue engineering scaffolds
(p 254-263)
Journal of Biomedical Materials Research 88B #1 (2009)
Abstract
1/9/2009
Reversible Immobilization onto PEG-based
Emulsion-templated Porous Polymers by Co-assembly of Stimuli Responsive
Polymers
(p 55-59)
Advanced Materials 21 #1 (2008)
Abstract
Sulfated glyco-block copolymers with specific receptor and growth factor
binding to support cell adhesion and proliferation
(1026-1035)
Biomaterials 30 #6 (2009)
11/21/2008
The development of peptide-based interfacial biomaterials for generating
biological functionality on the surface of bioinert materials
(277-286)
Biomaterials 30 #3 (2009)
The correlation between the adsorption of adhesive proteins and cell
behaviour on hydroxyl-methyl mixed self-assembled monolayers
(307-316)
Biomaterials 30 #3 (2009)
Light harvesting antenna on an amyloid scaffold
(6522 - 6524)
Chemical Communications #48 (2008)
Nanostructured Biomaterials for Regeneration
(p 3568-3582) V
Advanced Functional Materials 18 #22 (2008)
Abstract
From material to tissue: Biomaterial development,
scaffold fabrication, and tissue engineering
(p 3048-3067)
AIChE Journal 54 #12 (2008)
Abstract
11/7/2008
Cells anchored upon a thin organic film with different nano-mechanical
properties
(301-303)
Applied Surface Science 255 #2 (2008)
Scaffolds based on hyaluronan crosslinked with a
polyaminoacid: Novel candidates for tissue engineering application
(p 770-779)
Journal of Biomedical Materials Research 87A #3 (2008)
Abstract
Bacterial and Candida albicans adhesion on
rapid prototyping-produced 3D-scaffolds manufactured as bone replacement
materials
(p 933-943)
Journal of Biomedical Materials Research 87A #4 (2008)
Abstract
Endothelial cells derived from circulating
progenitors as an effective source to functional endothelialization of NaOH-treated
poly(
-caprolactone)
films
(p 964-971)
Journal of Biomedical Materials Research 87A #4 (2008)
Abstract
Granulocyte colony-stimulating factor
administration alters femoral biomechanical properties in C57BL/6 mice
(p 972-979)
Journal of Biomedical Materials Research 87A #4 (2008)
Abstract
Electrospinning of photocrosslinked and
degradable fibrous scaffolds
(p 1034-1043)
Journal of Biomedical Materials Research 87A #4 (2008)
Abstract
Acellular matrices derived from differentiating
embryonic stem cells
(p 1075-1085)
Journal of Biomedical Materials Research 87A #4 (2008)
Abstract
10/31/1008
Towards area-based in vitro metabolic
engineering: Assembly of Pfs enzyme onto patterned microfabricated chips
(p 1042-1051) Biotechnology
Progress 24 #5 (2008)
Abstract
10/31/1008
Three-dimensional culture for monoclonal antibody
production by hybridoma cells immobilized in macroporous gel particles
(p 1122-1131) Biotechnology
Progress 24 #5 (2008)
Abstract
10/24/2008
Hierarchical
Self-Organization of Nanomaterials into Two-Dimensional Arrays Using Functional
Polymer Scaffold
(p 3213-3218)
Advanced Functional Materials 18 #20 (2008)
Abstract
Micro-stamped surfaces for the patterned growth of neural stem cells
(4766-4774)
Biomaterials 29 #36 (2008)
Biocompatibility markers for the study of interactions between osteoblasts
and composite biomaterials
(45-5)
Biomaterials 30 #1 (2009)
Polymer model of
cancer cell adhesion to glycosaminoglycan substrates using the radius of
gyration
(p 70-77)
Journal of Applied Polymer Science 111 #1 (2009)
Abstract
9/26/2008
Distribution of lipid nanocapsules in different cochlear
cell populations after round window membrane permeation
(p 10-18)
Journal of Biomedical Materials Research 87B #1 (2008)
Abstract
Fabrication of porous, drug-releasing, biodegradable,
polymer scaffolds for sustained drug release
(p 121-131)
Journal of Biomedical Materials Research 87B #1 (2008)
Abstract
9/19/2008
High
yields of monomeric recombinant 
-interferon
from macroporous microcarrier cultures under hypothermic conditions
(p 832-838)
Biotechnology Progress 24 #4 (2008)
Abstract
8/15/2008
Membrane allocation profiling: A method to characterize three-dimensional
cell shape and attachment based on surface reconstruction
(3927-3935)
Biomaterials 29 #29 (2008)
New strategies for in vivo tissue engineering by mimicry of homing factors
for self-endothelialisation of blood contacting materials
(3936-3945)
Biomaterials 29 #29 (2008)
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Roger D. Corneliussen
Editor
Telephone: 610 883 0055
rcorneliussen@4spe.org
www.maropolymeronline.com
Copyright 2008 by Roger D. Corneliussen