Liposomes
9/14/2008
A liposome is a tiny bubble (vesicle), made out of the same material
as a cell membrane. Liposomes can be filled with drugs, and used to deliver
drugs for cancer and other diseases. Membranes are usually made of
phospholipids, which are molecules that have a head and a tail. The head is
attracted to water, and the tail, which is made of oil (hydrocarbon), is
repelled by water.
Wikipedia: http://en.wikipedia.org/wiki/Liposome
(11/8/2008)
A liposome suspended in water
Wikipedia: http://en.wikipedia.org/wiki/Liposome
(11/8/2008)
A liposome for drug delivery.
Wikipedia: http://en.wikipedia.org/wiki/Liposome
(11/8/2008)
Warning: Sometimes the older links no longer work. Go to the US Patent Patent number search page, copy the Patent number into the search box and search. For the articles, use your browser to go the Journal site.
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Notes
In nature, phospholipids are found in stable membranes composed of two
layers (a bilayer). In the presence of water, the heads are attracted to water
and line up to form a surface facing the water. The tails are repelled by water,
and line up to form a surface away from the water. In a cell, one layer of heads
faces outside of the cell, attracted to the water in the environment. Another
layer of heads faces inside the cell, attraced by the water inside the cell. The
hydrocarbon tails of one layer face the hydrocarbon tails of the other layer,
and the combined structure forms a bilayer.
Wikipedia: http://en.wikipedia.org/wiki/Liposome
(11/8/2008)
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Review Articles
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US Patents
11/11/2008
7,449,197
Liposome formulation of 6,9-bis[(2-aminoethyl)-amino]benzo[g]isoquinoline-5,
10-dione dimaleate
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Articles
2/20/2009
Near-IR Remote Release from Assemblies of Liposomes and
Nanoparticles
(p 1807-1809)
Angewandte Chemie International Edition 48 #10 (2009)
Abstract
2/6/2009
Structural and calorimetrical studies of the effect of different
aminoglycosides on DPPC liposomes
(116-121)
Colloids and Surfaces B: Biointerfaces 69 #1 (2009)
Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes
suppresses the angiogenesis in a dorsal air sac mouse model
(18-25)
Journal of Controlled Release 133 #4 (2009)
Improved transfection of spleen-derived antigen-presenting cells in culture
using TATp-liposomes
(41-46)
Journal of Controlled Release 133 #4 (2009)
Silica-lipid hybrid (SLH) microcapsules: A novel oral delivery system for
poorly soluble drugs
(62-70)
Journal of Controlled Release 133 #4 (2009)
11/7/2008
Formation of solid lipid nanoparticles in a microchannel system with a
cross-shaped junction
(5600-5605)
Chemical Engineering Science 63 #23 (2008)
Pig skin structure and transdermal delivery of liposomes: A two photon
microscopy study
(12-20)
Journal of Controlled Release 132 #1 (2008)
10/31/1008
L-cysteine encapsulation in liposomes: Effect of phospholipids nature on
entrapment efficiency and stability
(399 413) Journal
of Microencapsulation 25 #6 (2008)
Vesicular aceclofenac systems: A comparative study between liposomes and
niosomes
(499 512)
Journal of Microencapsulation 25 #7 (2008)
10/24/2008
Enhancement of Gene Expression Efficiency Using Cationic Liposomes on Ovarian
Cancer Cells
(523 529) Drug
Delivery 15 #8 (2008)
10/10/2008
Reactive oxygen species play a central role in the activity of cationic
liposome based cancer vaccine
(22-28)
Journal of Controlled Release 130 #1 (2008)
Gene delivery to dendritic cells mediated by complexes of lipoplexes and
pH-sensitive fusogenic polymer-modified liposomes
(77-83)
Journal of Controlled Release 130 #1 (2008)
Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the
most efficient for tumor-specific treatment and imaging?
(107-114)
Journal of Controlled Release 130 #2 (2008)
Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a
novel drug-carrier system for experimental malignant gliomas
(146-153)
Journal of Controlled Release 130 #2 (2008)
Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent
liposomes
(266-274)
Journal of Controlled Release 130 #3 (2008)
Effect of hepatocyte growth factor encapsulated in targeted liposomes on
liver cirrhosis
(77-82)
Journal of Controlled Release 131 #1 (2008)
Effects of Amphiphilic Copolymers Bearing Short Blocks of Lipid-Mimetic Units
on the Membrane Properties and Morphology of DSPC Liposomes
(1106 1113)
Journal of Dispersion Science and Technology 29 #8 (2008)
9/26/2008
Iron-oxide embedded solid lipid nanoparticles for magnetically controlled
heating and drug delivery
( 785-793)
Biomedical Microdevices 10 #6 ( 2008)
9/12/2008
Preparation and characterization of complexes of liposomes with gold
nanoparticles
(246-252)
Colloids and Surfaces B: Biointerfaces 66 #2 (2008)
Systematic Procedures for
Formulation Design of Drug-Loaded Solid Lipid Microparticles: Selection of
Carrier Material and Stabilizer
(6091 6100)
Industrial & Engineering Chemistry Research 47 #16 (2008)
Abstract
9/5/2008
Polyelectrolyte-coated liposomes: Stabilization of the interfacial complexes
(43-52)
Advances in Colloid and Interface Science 142 #1-2 (2008)
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Roger D. Corneliussen
Editor
Telephone: 610 883 0055
rcorneliussen@4spe.org
www.maropolymeronline.com
Copyright 2008 by Roger D. Corneliussen