Hydrogels

7/26/2008

The hydrogel is soft, solid-like material consisting of a network of insoluble polymer chains in water.  The can contain over 99% water and can be formed from natural or synthetic polymers.  Because of their high water content, they behave much like living cells  The common desert. Jello is a very good example of a hydrogel. 

RDC 6/12/2008

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“Hydrogels may be uncrosslinked or crosslinked. Uncrosslinked hydrogels are able to absorb water but do not dissolve due to the presence of hydrophobic and hydrophilic regions. Covalently crosslinked networks of hydrophilic polymers, including water soluble polymers, are traditionally denoted as hydrogels in the hydrated state.”

Sawhney, US Patent 7,413,752 (8/19/2008) [9/6/2008]

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Acrylic Hydrogels

Alginate Hydrogels

Bioimaging

Cellulose Hydrogels

Chitosan Hydrogels

Controlled Drug Release

Cyclodextrin Hydrogels

Dextran Hydrogels

Filled Hydrogels

Hydrogel Biomaterials

Hydrogel Coatings

Hydrogel Film

Hydrogel Nanocomposites

Hyaluronic Acid Hydrogels

Hydrogel Implants

Hydrogel Nanoparticles

Hydrogel Scaffolds

Mixing Hydrogels

Photoluminescent Hydrogels

PLGA Hydrogels

Polyacetal Hydrogels

Polyacrylamide Hydrogels

Polyamine Hydrogels

Polyethylene Oxide (PEO) Hydrogels

Protein /Polypeptide Hydrogels
Superabsorbent Hydrogels

Warning:  Sometimes the older links no longer work.  Go to the US Patent number search page, copy the Patent number into the search box and search.  For the articles, use your browser to go the Journal site. 

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Notes 

Applications:
tissue engineering scaffolds
controlled release systems
sorbents
biosensors
disposable diapers
contact lenses
medical electrodes
explosives
breast implants
moisture absorbents in soil
bandages

Common hydrogel polymers include polyvinyl alcohol, acrylate polymers and copolymers.  Natural hydrogels are agarose, methylcellulose and hylaronan.  (RDC 6/12/2008)
(Wikipedia: http://en.wikipedia.org/wiki/Gel)

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“Hydrophilic polymeric materials suitable for use in forming hydrogels include poly(hydroxyalkyl methacrylate), poly(electrolyte complexes), poly(vinylacetate) cross-linked with hydrolyzable bonds, water-swellable N-vinyl lactams polysaccharides, natural gum, agar, agarose, sodium alginate, carrageenan, fucoidan, furcellaran, laminaran, hypnea, eucheuma, gum arabic, gum ghatti, gum karaya, gum tragacanth, locust beam gum, arabinogalactan, pectin, amylopectin, gelatin, hydrophilic colloids such as carboxymethyl cellulose gum or alginate gum crosslinked with a polyol such as propylene glycol, and the like.”

Sawhney, US Patent 7,413,752 (8/19/2008) [9/6/2008]

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Review Articles

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US Patents

11/4/2008

7,445,812
Process for making water-swellable material comprising coated water-swellable polymers

9/2/2008

7,420,013
 Mixtures of compounds comprising at least two double bonds and use thereof

8/26/2008

7,417,101
Thermo-responsive water-soluble polymers for viscosity switch

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Journal Articles

2/13/209

Effect of Pore-Forming Agent Type on Swelling Properties of Macroporous Poly(N-[3-(dimethylaminopropyl)]-methacrylamide-co-acrylamide) Hydrogels
(58 – 64)  Journal of Macromolecular Science Part A - Pure and Applied Chemistry 46 #1 (2009)Authors: Goumlkccedilen Birlik Demirel;  Tuncer Caykara;  Melike Demiray; Metin Guumlruuml

Radiation Synthesis and Characterization of Polyvinyl Alcohol/Methacrylic Acid-Gelatin Hydrogel for Vitro Drug Delivery
(170 – 178) Journal of Macromolecular Science Part A - Pure and Applied Chemistry 46 #2 (2009)

1/23/2009

Calcite Growth in Hydrogels: Assessing the Mechanism of Polymer-Network Incorporation into Single Crystals 
(p 470-473)
Advanced Materials 21 #4 (2009)
Abstract  

Synthesis and water absorbency of polyampholytic hydrogels with antibacterial activity 
(p 439-446)
Journal of Applied Polymer  Science 112 #1 (2009)
Abstract

Modeling and analysis of pH-electric-stimuli-responsive hydrogels
(1597-1610) Journal of Biomaterials Science. Polymer Edition 19 #12 (2008)

Effect of solvent state and isothermal conditions on gelation of methylcellulose hydrogels
(1611-1623) Journal of Biomaterials Science. Polymer Edition 19 #12 (2008)

Electron spin resonance studies of the effects of sterilization on poly(ethylene glycol) hydrogels 
(p 409-418)
Journal of Biomedical Materials Research 88A #2 (2009)
Abstract

1/16/2008

Iron Tris(bipyridine) PEG Hydrogels with Covalent and Metal Coordinate Cross-Links
(128–133) Biomacromolecules 10 #1 (2009)

1/9/2009

In situ steady state fluorescence (SSF) technique to study drying of PAAm hydrogels made of various cross-linker contents
(600-605) Chemical Engineering and Processing 48, #2 (2009)

11/21/2008

Temperature responsive pore-filled membranes based on a BSA/poly(N-isopropylacrylamide) hydrogel 
(p 27-34)
Advances in Polymer Technology 27 #1 (2008)
Abstract  

Modeling the effect of environmental solution pH on the mechanical characteristics of glucose-sensitive hydrogels
(690-700) Biomaterials 30  #4 (2009)

Cell adhesive hydrogels synthesised by copolymerisation of arg-protected Gly-Arg-Gly-Asp-Ser methacrylate monomers and enzymatic deprotection
(5951 - 5953) Chemical Communications #45 (2008)

Preparation of comb-type grafted hydrogels composed of polyacrylamide and chitosan and their use for DNA adsorption 
(p 1862-1868)
Journal of Applied Polymer  Science 111 #4 (2009)
Abstract

11/7/2008

Synthesis and characteristic of the thermo- and pH-sensitive hydrogel and microporous hydrogel induced by the NP-10 aqueous two-phase system
(3688-3699) European Polymer Journal 44  #11 (2008)

In situ formation of hydrogels as vitreous substitutes: Viscoelastic comparison to porcine vitreous 
(p 656-665)
Journal of Biomedical Materials Research 87A #3 (2008)
Abstract  

10/31/1008

Hydrogel based tissue mimicking phantom for in-vitro ultrasound contrast agents studies 
(p 338-345)
Journal of Biomedical Materials Research 87B #2 (2008)
Abstract

10/3/2008

Undesirable effects of heating on hydrogels 
(p 3420-3430)
Journal of Applied Polymer  Science 110 #6 (2008)
Abstract

9/19/2008

Facile fabrication of conducting polymer hydrogels via supramolecular self-assembly
(
4279 – 4281) Chemical Communications #36 (2008)

9/5/2008

101[2008]  Modelling leading to water entrapment point in thermally driven hydrogelation of methyl cellulose
e-Polymers (9/5/2008) (117)
[Abstract]

8/22/2008

Thermoresponsive Hydrogel Photonic Crystals by Three-Dimensional Holographic Lithography 
(p 3061-3065)
Advanced Materials 20 #16 (2008)
Abstract  

7/25/2008

Preparation of Homogeneous Hydrogels by Controlling the Crosslinker Reactivity and Availability
(769 – 775) Journal of Macromolecular Science Part A - Pure and Applied Chemistry 45 #9 (2008)

Anions bonded on the supramolecular hydrogel surface as the growth center of biominerals
(84-89) Colloids and Surfaces B: Biointerfaces 66 #1 (2008)

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Roger D. Corneliussen
Editor
Telephone: 610 883 0055
rcorneliussen@4spe.org

www.maropolymeronline.com

Copyright 2009 by Roger D. Corneliussen